The Protein Man's Blog | A Discussion of Protein Research

Cysteine is one of the most reactive amino acid residue owing to the thiol (-SH) group, thiols can serve as an electron donor in different reactions. Cysteine thiols can form part of catalytic centre and can frequently participate in enzymatic reactions, not just that, cysteine thiols can also undergo a variety of covalent post-translational modifications (PTMs) and formation of disulphide bonds. The thiol modifications can act as important mediators of redox signalling and protein function regulation.

Prion diseases (also referred to as transmissible spongiform encephalopathies, or TSEs) are a group of progressive, untreatable, and fatal neurodegenerative conditions affecting both humans and animals. Generally, these conditions are characterized by long incubation periods (usually between 5 to 20 years), disruption in the normal tissue structure (resulting in holes and vacuole formation in the neurons), and the absence of an inflammatory response.

Despite the advances in modern medicine, no one knows for sure what causes amyotrophic lateral sclerosis (ALS), also called Lou Gehrig’s disease. Scientists can only theorize and speculate as to what causes it, but they still don’t have a conclusive answer to this question.